So the rule of thumb that I've come to learn is, for bear/hog/etc, you want FMJ rounds, preferably in a +p loading. You need the velocity to penetrate. The vitals on hogs in particular are pretty deep in, and that's some very hard tissue to go through. 45 vs 10mm, I'll take 10mm every day of the week. You have a better chance of getting the penetration that you need.But I don't think it's as simple as FPE. The FPE has to transfer to the target and in the right places. I would think the 45 caliber of 460R over 41mag's ~43 caliber or 10mms 40cal would transfer that FPE into the target more quickly, with less chance to over penetrate and the bullet leave with energy still left not transferred. But, bears hearts beat very slow and they might not be deterred by flesh wounds/pain. I think the bear central nervous system as a target would be the closest to a reliable way to survive. To penetrate into the bear, would the .45" be the best choice or would it lose energy too quickly? I understand this is where sectional density comes in - the bullet may have to displace more tissue to penetrate but if it has a higher relative weight to the more narrow projectile it's momentum can penetrate. 10mm seems to top at 200gr. 460 can use 45acp bullets and plenty of 255gr hard cast around.
Ultimately though, the statistics I've seen on bear attacks show the most important thing is getting as many rounds on target as possible. For bear, at least, getting more 9mm rounds on target is better than getting only a couple rounds of 10mm or 45. Hogs are a little more difficult to penetrate with the smaller round, hence why 10mm is widely regarded as one of the better options. Here is an article RE bear attacks sorted by caliber used in defense with pistol. Defense Against Bears with Pistols: 97% Success rate, 37 Incidents
I really wish there was a 10mm conversion for the FNX, but it's pretty much Springfield or Glock for that caliber, unless you want half the capacity.