i love my wife as well, she wanted a pistol to shoot so i got her a glock 19 9mm, but i don't advise that for everyone. just because you think she'll like it doesn't mean she will. the main reason i got a G19 was because i love glocks and if she didn't like it i would adopt it and get her something else, well my plan backfired.
what i've learned is women have different needs than men, for example my wife could not handle the 10-12lb trigger pull on most DAO and DA/SA firearms, but i did not feel comfortable with getting her a SA 1911 for a 3.5lb trigger pull, she has very small hands so something with an adjustable back strap would have been better. safeties i would advise against but proficient firearms handling is paramount (no finger on the trigger, gun pointed down range), and make sure she can reach all the controls (slide stop, magazine release) my wife has a hard time with the slide stop on the glock and usually pulls back on the slide to charge the weapon.
my suggestion is look at something in .32 or .380, but make sure they have good ergonomics (NO funny magazine releases) and a nice trigger, i would suggest something like the sig p232 if they still make it or a beretta .380
oh and just the other day my wife told me she put a beretta 20 gauge shotgun on layaway without me going into the store to look at it with her, i guess i've created a monster and my gun funds will be shared from now on.