Generally the ergonomics of the FN weapons are very well thought out in my opinion. Another good feature is the take down lever. It is quite easy to manipulate even with gloved or injured hands.
I have some first hand, so to speak, experience about this. I am a mechanic and live in the Mid West. It is winter and cold here, and my hands take a beating. Finger tips get split and dried out and it is often quite painful to do certain tasks, such as operating the take down mechanism on my only Glock. Man that hurt. Not so on my FNP 40.
Some serious thought went into these pistols.