If you are an accuracy nut and/or want to shoot at the range consistently every 25 and 50 yards then I would sight it for 50. If going this route, it may help to do 25 first because it might miss the paper at 50 right off the bat.
If, on the other hand, you are going to use it for fun or SD mainly, then I would do 25 or 15 yds. They are factory sighted for 25 yds with SS195. Oh yeah, different ammo changes point of impact so, keep the same type throughout the process
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