I use a TLR-2 on my FN-45, and HK P2000. What an outstanding piece of kit this unit it. Found mine for just under $220.
I've zeroed it for 25 feet, since if I have to use the weapon/laser in the house, this is about the distance it will be at. Did this at the range with paper. Pulled the trigger, and a black hole appeared where the last dot used to be. Cool.
Anything closer, you're going to hit your target. Anything farther, and you'll probably still hit the target, or at least scare the crap out of them when they see the dot.
The elevation and side-to-side tuning of the laser is pretty easy to manage with a small hex driver. That remains part of my took kit in the range and bug-out bags.
As an aside on their CS... Like a complete tool, I dropped my TLR and bent the front bezel. Unit still worked great, put it back on the weapon, and it did not lose its zero. That was impressive. I called up Streamlight to get another bezel, explaining I damaged the bezel and fully expected to pay for a new one. They sent one to me for free.
It's stuff like that that makes people customers for life. +1 to Streamlight.